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Immune-Mediated Polyarthritis in Dogs

Richard E. Goldstein, DVM, DACVIM (Small Animal Internal Medicine)

What is immune-mediated polyarthritis?
Arthritis means inflammation within a joint. Poly- means that multiple (more than two) joints are involved and immune-mediated means that the inflammation is caused by an invasion of white cells from the immune system into the joints. The kinds of white cells that invade joints are typically neutrophils. Neutrophils are meant to fight bacteria and other foreign agents invading the body. In doing so, they release large amounts of irritating substances from within their cells into the surrounding tissue. Unfortunately, in your dog's case these substances are being released in the joints, causing swelling, pain, loss of appetite, and fever.

What are the symptoms of immune-mediated polyarthritis?
The symptoms of immune-mediated polyarthritis can be variable and include the following:

  • Dogs are reluctant to rise and to walk, or may cry out when rising or walking
  • Dogs may try to walk gently to alleviate their pain. Therefore they sometimes appear to walk on their toes, hunched over with a stiff gait; something that looks like they are walking on hot coals or eggshells.
  • Some dogs exhibit back or neck pain, as the spine is also made up of many joints between each vertebra.
  • When examined closely, many dogs will have swollen joints. The joints may also be quite painful when mild pressure is applied to their surface or when they are manipulated.
  • Sometimes, fever, lethargy, and/or a decreased appetite are the only abnormalities that you or even your veterinarian can see. In such cases investigating the joints by careful physical examination and sampling fluid from the joints by performing joint taps are good ideas.

What tests are needed?
The diagnosis of immune-mediated polyarthritis is first suspected because a dog has appropriate symptoms. The diagnosis can only be confirmed by the analysis of joint fluids:

  • Samples of joint fluid can be readily obtained from dogs' joints, especially when they are swollen.
  • This process ("joint taps") involves placing a small needle attached to a syringe into the joint space, removing a few drops of fluid, and evaluating the contents under a microscope.
  • If indicated, your veterinarian may send a fluid sample to a laboratory for evaluation and possibly for a bacterial culture as well.
  • Although joint taps may be associated with some discomfort, the procedure is usually quick and rarely requires anesthesia.

Immune-mediated polyarthritis is usually an acute (rapidly developing) process, and is very different from what is commonly called "arthritis" or degenerative joint disease. The latter is a slow degenerative process that is associated with damage to the cartilage in the joints. It, too, is associated with pain but typically not with the same degree of pain and not with marked joint swelling, fever and a poor appetite.

Another type of arthritis is septic arthritis. This is caused by a primary bacterial infection within the joint itself. Septic arthritis usually affects one joint but can affect more than one. Sometimes differentiating between septic arthritis and immune-mediated arthritis is difficult. In both cases analysis of joint fluid will show large amounts of neutrophils. If bacteria are seen in the joint fluid analysis under a microscope or if bacteria are grown in a culture then the diagnosis of septic arthritis is substantiated. That may take quite a few days and frequently, even if there are bacteria seen, they do not grow in the culture. In some cases your veterinarian will not be able to be sure and might have to treat for immune-mediated as well as septic arthritis. Another hint that can be used is that septic arthritis usually affects the larger joints (knees, hips, elbows), whereas immune-mediated arthritis usually affects the smaller joints like carpi (wrists) and hocks (ankles).

What causes immune-mediated polyarthritis?
Why did your dog get immune-mediated polyarthritis? Why is your dog's immune system attacking his or her own joints? Two broad possibilities follow:

1. Secondary/systemic disease
2. Primary/idiopathic disease

Your dog's immune system problems may be secondary to an additional systemic disease. This other disease has caused the immune system to overreact and to lose some of its self-control, so instead of just fighting the primary disease it also starts attacking your dog's own tissues. Diseases that can cause this phenomenon are those that cause a strong reaction of the immune system such as infectious diseases and cancer. Infectious disease can include specific types of bacteria that are carried by ticks and frequently cause immune-mediated joint disease like ehrlichia or lyme disease, or any chronic (long lasting) bacterial, viral, or fungal infection.

Cancer elsewhere in the body can also arouse the immune system and cause it to overreact and attack the joints. Therefore after diagnosing immune-mediated joint disease in your dog your veterinarian may need to perform additional diagnostic testing including blood and urine testing and possibly x-rays and/or ultrasound to try and find an "underlying" disease.

Treating the immune disease will be much more successful if such an underlying disease can be found and treated. This type of secondary immune-mediated disease can happen in other body systems along with the joints. Such abnormalities may include destruction of your dog's red cells (cells that carry oxygen in the blood) or platelets (cells active in the clotting process). These could result in an anemia or bleeding. Other common organs attacked by the immune system are skin and kidneys. Once your veterinarian diagnoses immune-mediated disease in one other organ, it is wise to look for evidence of disease in other organs as well.

If no underlying disease is found, your dog may have "primary" or "idiopathic" immune-mediated polyarthritis. In this case the immune system has attacked the joints for no apparent reason. Just like with secondary immune-mediated polyarthritis, the same process may be going on in the other body systems as well.

What treatment is needed?
When recommending a treatment plan for your dog, your veterinarian will take into account the possibility of underlying infectious or cancerous disease. If such a disease is identified and can be treated, the joint disease may resolve as the underlying disease resolves. Unfortunately, this is usually not the case. Many times your veterinarian will send off blood tests looking for infectious causes of polyarthritis and then have to wait weeks for the result. In the mean time it is usually safe to start antibiotic therapy in the event that bacteria are involved. Doxycycline is an antibiotic commonly used for this purpose since it works well against many bacteria that can cause polyarthritis. Other antibiotics can be used as well.

When the chances of an infectious cause for your dog's polyarthritis are ruled out or deemed unlikely then treatment for primary or idiopathic immune-mediated polyarthritis may be prescribed. The goal of treatment in this setting is immunosuppression, or shutting down the immune system. Prednisone (a steroid) is the most common medication used for this purpose. There is a good chance that your dog will feel much better within a few days of steroid therapy. But remember, this treatment will likely have to be given for months! Stopping too early may make symptoms return. Your veterinarian may prescribe a high dose of prednisone initially and then slowly taper the dose.

Side effects of steroids are common and they include the following:

  • Increased drinking
  • Increased urination
  • Increased appetite
  • Panting
  • Weakness
  • Rarely, more severe side effects such as blood clots, liver disease, or diabetes

Some veterinarians will treat with an additional immunosuppressive drug like azathioprine along with the prednisone. Your veterinarian will have to recheck your dog every few weeks and likely repeat the joint taps as the medications are tapered. Don't rush! Better to be patient than to have a recurrence of the disease.

Prognosis
Most cases of immune-mediated polyarthritis are treatable and your dog has a good chance to eventually make a full recovery.

Updated 8/19/2008: Audrey Cook, BVM&S, MRCVS, DACVIM (Small Animal Internal Medicine)
Posted 8/26/2008