Building the Immune Environment of Cancer
Course Overview
This lecture will describe the formation, remodeling, maintenance, and function of the immune landscape of cancer. Specifically, the formation of the tumor-immune environment at the earliest stages of tumor development, its heterogeneity and constantly evolving phenotypes, the physiological processes that regulate innate and adaptive immune responses, and the role of adaptive evolution within the tumor will be discussed in the context of how they determine the duration and efficacy of anti-tumor immune responses. This presentation is organized in three topics. The first topic covers the formation of the tumor immune environment and is subdivided into three sections that will focus on (1) inflammation and cancer, (2) the immune response to cancer, and (3) the development of the tumor-immune environment. The second topic describes a cross sectional view of the tumor-immune landscape and is also subdivided into three sections that will focus on (1) the definition of the tumor-immune landscape, (2) the composition and complexity of the tumor-immune landscape, and (3) the clinical significance of the tumor-immune landscape. The final topic describes the evolution of the tumor-immune landscape and is subdivided into four sections that will focus on (1) the innate response to tumor formation, (2), the dynamic interactions between the tumor and the immune system, (3) the role of mutational neoantigens in the anti-tumor immune response, and (4) immunoediting, or the success or failure of anti-tumor immunity. An important conclusion from this lecture is that breaking the tumor immunosuppressive barrier(s) is an absolute condition that must be achieved if cancer immunotherapies are to be successful.
Learning Objectives:- Appreciate the steps and the mechanisms that lead to the formation of the immunosuppressive barrier
- Recognize the heterogeneity of the tumor-immune landscape and the limitations of reducing that landscape to a few types or categories
- Understand the opportunities and limitations for immunomodulation and immunotherapy across the diversity of cancers
RACE Application Status
This module has been submitted and approved for 1.0 hours of continuing education credit in jurisdictions which recognize AAVSB RACE approval.
For additional questions, please contact us at Learning@ACVIM.org.
Presenter
Jaime Modiano, VMD, PhD
Dr. Jaime Modiano holds the Alvin and June Perlman Endowed Chair of Animal Oncology and is Director of the Animal Cancer Care and Research Program of the College of Veterinary Medicine and the Masonic Cancer Center, University of Minnesota. He completed his training through the Veterinary Medical Scientist Training Program (VMD, PhD) at the University of Pennsylvania, followed by a residency in Clinical Pathology at Colorado State University and a post-doctoral fellowship at the National Jewish Center for Immunology and Respiratory Medicine. Before joining the University of Minnesota, he served on the faculties of Texas A&M University and the University of Colorado Health Sciences Center.
Sponsored by
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Course Information
- Date: Anytime
- Duration: 60 Minutes
- Location: Virtual
- Audience: ACVIM, ECEIM, ECVIM-CA and ECVN Diplomates and candidates
- Specialty: Oncology
- Type: On Demand
- CE Hours: 1.0
Cost
ACVIM Diplomates and candidates: $0
ECEIM, ECVIM-CA and ECVN Diplomates and candidates: $30
Nonmembers: $50
Already Registered?
On Demand courses are hosted in ACVIM’s online learning system ACVIM Online, powered by VetBloom.
Individual access has been provided to enrolled participants via email or log in using your ACVIM.org username and password. You will be taken to your Learner Dashboard where any course you are enrolled in will show in the Current Learning section.
All ACVIM Oncology Diplomates and Candidates have been automatically enrolled in each Science of Veterinary
Questions? Check out the ACVIM Online Instructional Guide or contact
Learning@ACVIM.org.
Series Overview
The ACVIM has developed ten (10) Science of Veterinary Oncology (SOVO) online courses that are currently available and complimentary for ACVIM members with four (4) more in development and coming soon. These modules offer foundational building blocks of core knowledge areas pertaining to veterinary oncology and were developed based on the Job Task Analysis review performed in 2016. All modules are led by industry experts and each module is RACE-approved.