Cell Signaling and Signal Transduction Inhibitors

On Demand

Course Overview

The objective of this module is to provide an overview of signal transduction in both normal and neoplastic cells, how dysregulated signaling contributes to tumor growth and methods used to target aberrant signaling in cancer cells. This module covers the following subjects:

  • Normal signal transduction and cellular homeostasis
  • Major signal transduction pathways in cells (PI3 kinase, MAP Kinase, etc.)
  • Causes of dysregulated signaling in cancer cells (e.g., mutations, etc.)
  • Role of dysregulated signaling in supporting cancer cell growth/survival
  • Methods and mechanisms to aberrant signal transduction in cancer (e.g., small molecular inhibitors)
  • Resistance to small molecule inhibitors
  • Application of small molecule inhibitors to veterinary cancers

RACE Application Status

This module has been submitted and approved for 1.5 hours of continuing education credit in jurisdictions which recognize AAVSB RACE approval.

For additional questions, please contact us at Learning@ACVIM.org.




Cheryl London, DVM, PhD, DACVIM (Oncology)

Cheryl London, DVM, PhD, DACVIM (Oncology)
Anne Engen and Dusty Professor of Comparative Oncology, Cummings School of Veterinary Medicine and School of Medicine and School of Medicine at Tufts University
Associated Faculty Professor, Ohio State University College of Veterinary Medicine 


Cheryl London, DVM, PhD, Diplomate ACVIM (Oncology) is the Anne Engen and Dusty Professor of Comparative Oncology at The Cummings School of Veterinary Medicine and School of Medicine at Tufts University, as well as an Associated Faculty Professor at the Ohio State University College of Veterinary Medicine (OSU CVM). She is Director of the Veterinary Clinical Trials Office at the Cummings School and Director of the Research Collaboration Team and One Health Module at the Tufts Clinical Translational Science Institute.  

Dr. London earned her DVM at Tufts University, completed her Residency in Medical Oncology at the University of Wisconsin-Madison, and her PhD in Immunology at Harvard University, where she was also a postdoctoral fellow in the Department of Pathology. Following completion of her training, she was an Assistant Professor in the UC Davis Department of Surgical and Radiological Sciences at the School of Veterinary Medicine for six years. She then moved to The Ohio State University College of Veterinary Medicine where she held the Thekla R. and Donald B. Shackelford Professorship in Canine Medicine. Dr. London’s research interests center primary on targeted therapeutics and she has over 25 years of experience in comparative and translational oncology drug development leveraging spontaneous models of cancer in dogs.


Sponsored by

Course Information

  • Date: Anytime
  • Duration: 105 Minutes
  • Location: Virtual
  • Audience: ACVIM, ECEIM, ECVIM-CA and ECVN Diplomates and candidates
  • Specialty: Oncology
  • Type: On Demand
  • CE Hours: 1.5



ACVIM Diplomates and candidates: $0

ECEIM, ECVIM-CA and ECVN Diplomates and candidates: $45

Nonmembers: $75



 Already Registered?

On Demand courses are hosted in ACVIM’s online learning system ACVIM Online, powered by VetBloom.


Individual access has been provided to enrolled participants via email or  log in using your ACVIM.org username and password. You will be taken to your Learner Dashboard where any course you are enrolled in will show in the Current Learning section.

All ACVIM Oncology Diplomates and Candidates have been automatically enrolled in each Science of Veterinary

Questions? Check out the ACVIM Online Instructional Guide  or contact  Learning@ACVIM.org


Series Overview

The ACVIM has developed ten (10) Science of Veterinary Oncology (SOVO) online courses that are currently available and complimentary for ACVIM members with four (4) more in development and coming soon. These modules offer foundational building blocks of core knowledge areas pertaining to veterinary oncology and were developed based on the Job Task Analysis review performed in 2016. All modules are led by industry experts and each module is RACE-approved. 




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