Genomic Instability
Course Overview
DNA damage response mechanisms protect mammalian cells from genomic instability and phenotypes such as aging and cancer. In contrast to normal cells, tumors exhibit extreme genomic instability, which can occur at the level of DNA as well as at the chromosomal level. This course reviews the causes and consequences of genomic instability, including manifestations in DNA and chromosomes; the course also provides a thorough review of cellular DNA damage response mechanisms, including detection of damage, checkpoint signaling, and recruitment of repair factors.
Learning Objectives
- List causes and consequences of genomic instability
- Define the following and explain their significance in cancer: chromosomal deletion, chromosomal translocation, chromosomal inversion, aneuploidy, polyploidy, internal tandem duplication and provide key examples
- Explain the difference between and the significance of somatic and germline mutations
- Describe the differences between single strand and double strand DNA breaks in terms of impact on the cell and repair processes involved
- Name the kinases involved in signaling for DNA damage
- Explain the following: mismatch repair, nucleotide excision repair, base excision repair, microsatellite instability. Name cancers or cancer syndromes associated with deficiencies in these repair processes
- Recognize the key players in checkpoint signaling and DNA repair including the DNA damage response pathway components that are currently undergoing evaluation as therapeutic targets
RACE Application Status
This module has been submitted and approved for 1.0 hours of continuing education credit in jurisdictions which recognize AAVSB RACE approval.
For additional questions, please contact us at Learning@ACVIM.org.
Presenter
Kelly R. Hume, DVM, DACVIM (Oncology)
Associate Professor, Department of Clinical Sciences
Cornell University
Dr. Hume received her Doctorate of Veterinary Medicine from Auburn University. She completed a residency in medical oncology at North Carolina State University in 2008 and a research fellowship in the Department of Biomedical Sciences at Cornell University in 2010. She is currently an associate professor in the Department of Clinical Sciences at Cornell University. Her research focuses on understanding how DNA damage response and repair pathways modulate tumor suppression and chemosensitivity, with the ultimate goal of determining how the genetics of a given tumor can be used to best manipulate therapeutic combinations.
Sponsored by
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Course Information
- Date: Anytime
- Duration: 60 Minutes
- Location: Virtual
- Audience: ACVIM, ECEIM, ECVIM-CA and ECVN Diplomates and candidates
- Specialty: Oncology
- Type: On Demand
- CE Hours: 1.0
Cost
ACVIM Diplomates and candidates: $0
ECEIM, ECVIM-CA and ECVN Diplomates and candidates: $30
Nonmembers: $50
Already Registered?
On Demand courses are hosted in ACVIM’s online learning system ACVIM Online, powered by VetBloom.
Individual access has been provided to enrolled participants via email or log in using your ACVIM.org username and password. You will be taken to your Learner Dashboard where any course you are enrolled in will show in the Current Learning section.
All ACVIM Oncology Diplomates and Candidates have been automatically enrolled in each Science of Veterinary
Questions? Check out the ACVIM Online Instructional Guide or contact
Learning@ACVIM.org.
Series Overview
The ACVIM has developed ten (10) Science of Veterinary Oncology (SOVO) online courses that are currently available and complimentary for ACVIM members with four (4) more in development and coming soon. These modules offer foundational building blocks of core knowledge areas pertaining to veterinary oncology and were developed based on the Job Task Analysis review performed in 2016. All modules are led by industry experts and each module is RACE-approved.