Invasion and Metastasis

On Demand

Course Overview

Metastasis is a common cause of death in patients with solid tumors. Research in this area may lead to better identification of patients at risk of developing metastasis in addition to improved therapies for patients with metastatic disease. This lecture is intended to provide a basic overview of tumor invasion and metastasis. We will start with an introduction to the steps of the metastatic cascade, including a review of foundational experimental and clinical evidence that has led to our current understanding of this process.  We will then cover the fundamentals of tumor progression, as it relates to metastatic heterogeneity, and review evidence supporting Stephen Paget’s original “seed and soil” hypothesis. With this knowledge we will move into examples of how stromal and immune cells may interact with tumor cells to regulate or facilitate individual steps of the metastatic cascade. Finally, we will review current concepts and trends in metastasis research including the potential fate of disseminated tumor cells, importance of the metastatic niche, reactivation of dormancy, and implications for the clinical therapy of metastasis.  

Learning Objectives

  • Recall the steps of the metastatic cascade and the 'decathlon' analogy
  • Assimilate the fundamental experiments that have led to our understanding of the metastatic cascade
  • Provide an example of paracrine signaling or cross-talk between tumor tissues and stromal tissues/immune cells and explain how this might lead to tumor progression or metastasis
  • Recognize strengths and shortcomings of common in vitro and in vivo techniques capable of evaluating metastasis
  • Understand the clinical implications (and limitations) of detecting tumor cells within the circulation, regional nodes or distant tissues
  • Assimilate and discuss with clients, in lay terms, the metastatic cascade and how it relates to their pet's recommended treatment
  • Recognize and define the concepts of "seed and soil", "foraging", tumor heterogeneity, exosomes and tumor dormancy

RACE Application Status
This module has been submitted and approved for 1.25 hours of continuing education credit in jurisdictions which recognize AAVSB RACE approval.

For additional questions, please contact us at Learning@ACVIM.org.



Robert B. Rebhun, DVM, PhD, DACVIM (Oncology)

Robert B. Rebhun, DVM, PhD, DACVIM (Oncology) 
Professor and Maxine Endowed Chair in Medical Oncology 
UC Davis School of Veterinary Medicine


Dr. Rebhun currently serves as Professor and Maxine Adler Endowed Chair in Medical Oncology at the University of California-Davis School of Veterinary Medicine. Dr. Rebhun is a second-generation veterinarian who received both his Bachelor of Science and Doctorate of Veterinary Medicine degrees from Cornell University. He then earned a Ph.D. degree in Cancer Biology from the University of Texas Health Science Center at Houston/M.D. Anderson Cancer Center Graduate School of Biomedical Sciences under the mentorship of Dr. Isaiah Fidler. Dr. Rebhun went on to complete a medical oncology residency at the Flint Animal Cancer Center, at the Colorado State University College of Veterinary Medicine and Biomedical Sciences. Dr. Rebhun’s research is focused on comparative and translational oncology, with specific interests in metastasis, novel therapeutics, and immunotherapy. He has successfully maintained NIH funding since first being awarded a K01 SERCA award in 2011. Dr. Rebhun also serves as Chair of Admissions for the Graduate Group in Integrative Pathobiology at UC Davis and is Associate Director of the Cancer Program within the UC Davis Center for Companion Animal Health.  

Sponsored by

Course Information

  • Date: Anytime
  • Duration: 75 Minutes
  • Location: Virtual
  • Audience: ACVIM, ECEIM, ECVIM-CA and ECVN Diplomates and candidates
  • Specialty: Oncology
  • Type: On Demand
  • CE Hours: 1.25



ACVIM Diplomates and candidates: $0

ECEIM, ECVIM-CA and ECVN Diplomates and candidates: $45 

Nonmembers: $75



 Already Registered?

On Demand courses are hosted in ACVIM’s online learning system ACVIM Online, powered by VetBloom.


Individual access has been provided to enrolled participants via email or  log in using your ACVIM.org username and password. You will be taken to your Learner Dashboard where any course you are enrolled in will show in the Current Learning section.

All ACVIM Oncology Diplomates and Candidates have been automatically enrolled in each Science of Veterinary

Questions? Check out the ACVIM Online Instructional Guide  or contact  Learning@ACVIM.org


Series Overview

The ACVIM has developed ten (10) Science of Veterinary Oncology (SOVO) online courses that are currently available and complimentary for ACVIM members with four (4) more in development and coming soon. These modules offer foundational building blocks of core knowledge areas pertaining to veterinary oncology and were developed based on the Job Task Analysis review performed in 2016. All modules are led by industry experts and each module is RACE-approved. 




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