Tumor Microenvironment

On Demand

Course Overview

This lecture will describe the tumor microenvironment, beginning with the mechanisms that lead to the creation of a tumor niche and continuing through the steps that allow it to evolve to favor tumor growth and dissemination. The tumor microenvironment refers to the complex ecosystem in which tumor cells reside and interact. The key take-home messages in this lecture are that (1) Tumors are tissues, and the temporal and spatial organization of those tissues is a critical determinant of tumor biological behavior. (2) Mutations of driver genes are essential events required to initiate tumors (and can be unique to tumors, individuals, and/or species), but ultimately, selective pressures to establish a niche and form a new, organized tissue within the constraints of its anatomical location are critical determinants of tumor progression. And finally, (3) strategies to detect and disrupt the formation of the tumor microenvironment provide a new frontier for safe and effective cancer treatment, control, and prevention.

Learning Objectives
  • Learners will have an improved understanding of the formation of the tumor niche and the evolution of the tumor microenvironment.
  • Learners will recognize that natural selection dictates the evolution towards convergent molecular programs, regardless of mutational drivers, to create predictable tumor phenotypes.
  • Learners will appreciate opportunities for therapies directed towards the tumor microenvironment to more effectively manage malignant cancers.

RACE Application Status
This module has been submitted and approved for 1.0 hours of continuing education credit in jurisdictions which recognize AAVSB RACE approval.

For additional questions, please contact us at Learning@ACVIM.org.



Jaime Modiano, VMD, PhD

Jaime Modiano, VMD, PhD
Perlman Professor of Oncology and Comparative Medicine
Department of Veterinary Clinical Sciences
College of Veterinary Medicine and Masonic Cancer Center, University of Minnesota


Dr. Jaime Modiano holds the Alvin and June Perlman Endowed Chair of Animal Oncology and is Director of the Animal Cancer Care and Research Program of the College of Veterinary Medicine and the Masonic Cancer Center, University of Minnesota. He completed his training through the Veterinary Medical Scientist Training Program (VMD, PhD) at the University of Pennsylvania, followed by a residency in Clinical Pathology at Colorado State University and a post-doctoral fellowship at the National Jewish Center for Immunology and Respiratory Medicine. Before joining the University of Minnesota, he served on the faculties of Texas A&M University and the University of Colorado Health Sciences Center.

Dr. Modiano has also worked in the private sector as founder of Half Moon Bay Biotechnology, LLC and of ApopLogic Pharmaceuticals, Inc., Managing Partner for Veterinary Research Associates, LLC, and Director of Cancer Immunology and Immunotherapy for the Donald Monk Cancer Research Foundation. Through his research, Dr. Modiano seeks to understand how and why cancer happens, as well as to develop strategies to improve the health and wellbeing of companion animals and humans. His research has been supported by federal and private sources without interruption for over 25 years. He has co-authored more than 500 scientific papers, abstracts, presentations, and book chapters focused on immunology, cancer biology and genetics, and therapeutic innovations for cancer and immune-mediated diseases.

Sponsored by

Course Information

  • Date: Anytime
  • Duration: 60 Minutes
  • Location: Virtual
  • Audience: ACVIM, ECEIM, ECVIM-CA and ECVN Diplomates and candidates
  • Specialty: Oncology
  • Type: On Demand
  • CE Hours: 1.0



ACVIM Diplomates and candidates: $0

ECEIM, ECVIM-CA and ECVN Diplomates and candidates: $30 

Nonmembers: $50



 Already Registered?

On Demand courses are hosted in ACVIM’s online learning system ACVIM Online, powered by VetBloom.


Individual access has been provided to enrolled participants via email or  log in using your ACVIM.org username and password. You will be taken to your Learner Dashboard where any course you are enrolled in will show in the Current Learning section.

All ACVIM Oncology Diplomates and Candidates have been automatically enrolled in each Science of Veterinary

Questions? Check out the ACVIM Online Instructional Guide  or contact  Learning@ACVIM.org


Series Overview

The ACVIM has developed ten (10) Science of Veterinary Oncology (SOVO) online courses that are currently available and complimentary for ACVIM members with four (4) more in development and coming soon. These modules offer foundational building blocks of core knowledge areas pertaining to veterinary oncology and were developed based on the Job Task Analysis review performed in 2016. All modules are led by industry experts and each module is RACE-approved. 




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