One of the revised hallmarks of cancer is dysregulated energy metabolism. This session will cover the historical and modern concepts of glucose utilization and energy generation in cancer, how it may affect tumor cell behavior, and strategies for intervention.The cancer stem cell theory states that tumor growth is driven by a small number of dedicated cancer stem cells (CSCs). These cells are endowed with the ability to self-renew (leading to unlimited cell division and maintenance of the stem cell pool), differentiate into non-CSCs and are intrinsically resistant to conventional therapeutics. This theory explains the clinical observations of almost inevitable tumor relapse after initially successful chemo and/or radiotherapy, and metastasis. This module reviews the biology of CSCs and provides insights into CSC plasticity, interaction with the niche, tumor repopulation and clinical implications of therapeutic response.
- Explain the difference between the clonal evolution model and the CSC model
- Define a stem cell
- List the key characteristics of a CSCs
- Define cellular plasticity and explain why it is important within the tumor
- Describe the epithelial-to-mesenchymal transition
- Explain the Warburg effect
RACE Application Status
This module has been submitted and approved for 1.25 hours of continuing education credit in jurisdictions which recognize AAVSB RACE approval.
For additional questions, please contact us at Learning@ACVIM.org.