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Metastasis is a common cause of death in patients with solid tumors. Research in this area may lead to better identification of patients at risk of developing metastasis in addition to improved therapies for patients with metastatic disease. This lecture is intended to provide a basic overview of tumor invasion and metastasis. We will start with an introduction to the steps of the metastatic cascade, including a review of foundational experimental and clinical evidence that has led to our current understanding of this process. We will then cover the fundamentals of tumor progression, as it relates to metastatic heterogeneity, and review evidence supporting Stephen Paget’s original “seed and soil” hypothesis. With this knowledge we will move into examples of how stromal and immune cells may interact with tumor cells to regulate or facilitate individual steps of the metastatic cascade. Finally, we will review current concepts and trends in metastasis research including the potential fate of disseminated tumor cells, importance of the metastatic niche, reactivation of dormancy, and implications for the clinical therapy of metastasis.
RACE Application Status
This module has been submitted and approved for 1.25 hours of continuing education credit in jurisdictions which recognize AAVSB RACE approval.
For additional questions, please contact us at Learning@ACVIM.org.
Dr. Rebhun currently serves as Professor and Maxine Adler Endowed Chair in Medical Oncology at the University of California-Davis School of Veterinary Medicine. Dr. Rebhun is a second-generation veterinarian who received both his Bachelor of Science and Doctorate of Veterinary Medicine degrees from Cornell University. He then earned a Ph.D. degree in Cancer Biology from the University of Texas Health Science Center at Houston/M.D. Anderson Cancer Center Graduate School of Biomedical Sciences under the mentorship of Dr. Isaiah Fidler. Dr. Rebhun went on to complete a medical oncology residency at the Flint Animal Cancer Center, at the Colorado State University College of Veterinary Medicine and Biomedical Sciences. Dr. Rebhun’s research is focused on comparative and translational oncology, with specific interests in metastasis, novel therapeutics, and immunotherapy. He has successfully maintained NIH funding since first being awarded a K01 SERCA award in 2011. Dr. Rebhun also serves as Chair of Admissions for the Graduate Group in Integrative Pathobiology at UC Davis and is Associate Director of the Cancer Program within the UC Davis Center for Companion Animal Health.
ACVIM Diplomates and candidates: $0
ECEIM, ECVIM-CA and ECVN Diplomates and candidates: $45
On demand courses are hosted in ACVIM’s online learning system ACVIM Online, powered by VetBloom.
Individual access has been provided to enrolled participants via email or log in using your ACVIM.org username and password. You will be taken to your Learner Dashboard where any course you are enrolled in will show in the Current Learning section.
All ACVIM Oncology Diplomates and candidates have been automatically enrolled in each Science of Veterinary
The ACVIM has developed nine (9) Science of Veterinary Oncology (SOVO) online courses that are currently available and complimentary for ACVIM members with five (5) more in development and coming soon. These modules offer foundational building blocks of core knowledge areas pertaining to veterinary oncology and were developed based on the Job Task Analysis review performed in 2016. All modules are led by industry experts and each module is RACE-approved.